Blar i forfatter "Lunnan, Asbjørn"

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    • Characterization of a novel class of mutation (Short Patch Illegitimate Recombination) in Acinetobacter baylyi 

      Lunnan, Asbjørn (Master thesis; Mastergradsoppgave, 2013-05-20)
      In prokaryotes, genetic variability contributes to the adaptation to novel environmental conditions, to resistance against threats such as antimicrobial agents and viruses, and ultimately to bacterial evolution through selection and drift. Genetic variability is mainly generated through mutations, e.g. point mutations, deletions, insertions, inversions, and duplications/amplifications. In addition, ...

    • Substitutions of short heterologous DNA segments of intragenomic or extragenomic origins produce clustered genomic polymorphisms 

      Harms, Klaus; Lunnan, Asbjørn; Hulter, Nils; Mourier, Tobias; Vinner, Lasse; Andam, Cheryl P; Marttinen, Pekka; Fridholm, Helena; Hansen, Anders Johannes; Hanage, William P; Nielsen, Kaare Magne; Willerslev, Eske; Johnsen, Pål Jarle (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-27)
      In a screen for unexplained mutation events we identified a previously unrecognized mechanism generating clustered DNA polymorphisms such as microindels and cumulative SNPs. The mechanism, short-patch double illegitimate recombination (SPDIR), facilitates short single-stranded DNA molecules to invade and replace genomic DNA through two joint illegitimate recombination events. SPDIR is controlled by ...